Description 【募集の背景 / Purpose & Scope】 Recent advances in drug discovery targeting cancer have been remarkable, and Astellas is constantly challenging next-generation modalities such as cell therapy, gene therapy, and multifunctional antibodies, as well as new cancer biology. Under such circumstances, we have successfully delivered innovative treatment drugs such as XOSPATA, XTANDI, and PADCEV to cancer patients. Furthermore, we are currently promoting drug discovery research by combining multifunctional modality and the biological understanding of TME in the Primary Focus "Immuno-Oncology" established through our Focus Area approach. We are urgently recruiting people who will participate in the challenge of driving a paradigm shift in cancer treatment together with our team. We welcome applications from those who can persistently plan and carry out research with innovative ideas and a spirit of challenge, and lead research projects as a member of the global team. 【職務の内容 / Essential Job Responsibilities】 (雇入れ直後) The position is expected to lead drug discovery programs that utilizes genetically modified technology for cancer treatment, and will be in charge of the following tasks. 1. In view of science and trends in the ADC related field, establish next-generation ADCs that can be expected to have innovative therapeutic benefits 2. Design and synthesis of payloads, linkers and ADCs which includes investigation and analysis of patents, literatures and reviews related to our researching therapeutic area as well as carrying out organic reactions, conjugations, purifications and structure analysis to identify a compound suitable for clinical testing 3. CRO management for synthesis of small molecules to accelerate projects (変更の範囲) 会社内での全ての業務 【就業環境に関する要件 / Specific Physical or Environmental Requirements】

Commute to Tsukuba Research Center 【応募要件 / Qualifications】 ・Experience in promoting research project as a small team ・Advanced knowledge and experience in small molecule and ADC chemistry ・Experimental skills necessary to carry out ADC research (both small molecule synthesis and ADC conjugation) ・Business level communication skill in English (Japanese communication skill is not mandatory in case applicants are non-Japanese) ・PhD with 5+ years or MS with 8+ years of relevant experience in life science.

・Work experience at pharmaceutical companies and biotech companies ・post-doctoral experience in chemistry in the US ・Experience in next generation conjugation includes site-specific conjugation ・Experience working in global, cross-functional team consisting of different backgrounds ・Patent application experience

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